TIME TO GUIDELINE-DETERMINED MEDICAL THERAPY IN PATIENTS WITH DE NOVO HEART FAILURE: A RETROSPECTIVE POPULATION-BASED STUDY FROM ALBERTA, CANADA
نویسندگان
چکیده
BackgroundQuadruple therapy is recommended for the management of patients with heart failure (HF) and reduced ejection fraction (HFrEF), however, many in Canada are not yet on triple therapy. In order to provide background identify barriers quadruple therapy, this study, aim was explore time initiate a population-based cohort de novo HF.Methods ResultsAdult hospital or emergency department diagnosis HF between April 1, 2008, March 31, 2018, Alberta, were included, linked echocardiography data HFrEF (EF < 40%). Any treatment angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, mineralocorticoid antagonists captured if prescribed ?28 days filled at least once during 12 months after index episode. Patients no-, mono-, dual-, triple-therapy identified. Time calculated from zero 480 days, outcomes tracked up 2020. Among 29,103 HF, 15.6%, 44.2%, 32.2%, 8.0% received, respectively, no monotherapy, dual within 1-year 54.9% HFrEF. cohort, 9.5%, 27.5%, 41.6%, 21.4% received respectively The dual- mean 22.6 ± 47.7, 29.1 45.3, 32.1 44.6 among those who these therapies. younger, more likely be male, lower frequency renal impairment, chronic obstructive pulmonary diseases, but higher coronary artery disease, baseline natriuretic peptide, glomerular filtration rate, left ventricular levels compared their counterparts. had rates clinical mono- dual-therapy (Table).Conclusion HF. Quadruple Methods (Table). Adult Conclusion
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ژورنال
عنوان ژورنال: Canadian Journal of Cardiology
سال: 2022
ISSN: ['0828-282X', '1916-7075']
DOI: https://doi.org/10.1016/j.cjca.2022.08.126